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Ultrasensitive feedback control can improve robust gene expressions in cell populations, yet it usually requires large chemical productions that cause severe burden to cells. Inspired by `division-of-labor' in heterogeneous populations, we propose a bistable switch circuit that utilizes quorum sensing systems to coordinate heterogeneous phenotypes' behaviors. We show that ultrasensitivity emerges from a collection of parallel bistable switches in individual cells. When applied to feedback control of population level expressions, it can achieve robust reference tracking and adaptation to disturbances. In particular, we demonstrate that molecular sequestration enables tunable hysteresis in single switches, leading to a wide range of stable population level expressions. 

Lightning increases the atmosphere’s ability to cleanse itself by producing nitric oxide (NO), leading to atmospheric chemistry that forms ozone (O₃) and the atmosphere’s primary oxidant, the hydroxyl radical (OH). Our analysis of a 2012 airborne study of deep convection and chemistry demonstrates that lightning also directly generates the oxidants OH and the hydroperoxyl radical (HO₂). Extreme amounts of OH and HO₂were discovered and linked to visible flashes occurring in front of the aircraft and to subvisible discharges in electrified anvil regions. This enhanced OH and HO₂is orders of magnitude greater than any previous atmospheric observation. Lightning-generated OH in all storms happening at the same time globally can be responsible for a highly uncertain, but substantial, 2 to 16% of global atmospheric OH oxidation. 

Abstract The production of $$\pi ^{\pm }$$ π ± , $$\mathrm{K}^{\pm }$$ K ± , $$\mathrm{K}^{0}_{S}$$ K S 0 , $$\mathrm{K}^{*}(892)^{0}$$ K ∗ ( 892 ) 0 , $$\mathrm{p}$$ p , $$\phi (1020)$$ ϕ ( 1020 ) , $$\Lambda $$ Λ , $$\Xi ^{-}$$ Ξ - , $$\Omega ^{-}$$ Ω - , and their antiparticles was measured in inelastic proton–proton (pp) collisions at a center-of-mass energy of $$\sqrt{s}$$ s = 13 TeV at midrapidity ( $$|y|<0.5$$ | y | < 0.5 ) as a function of transverse momentum ( $$p_{\mathrm{T}}$$ p T ) using the ALICE detector at the CERN LHC. Furthermore, the single-particle $$p_{\mathrm{T}}$$ p T distributions of $$\mathrm{K}^{0}_{S}$$ K S 0 , $$\Lambda $$ Λ , and $$\overline{\Lambda }$$ Λ ¯ in inelastic pp collisions at $$\sqrt{s} = 7$$ s = 7  TeV are reported here for the first time. The $$p_{\mathrm{T}}$$ p T distributions are studied at midrapidity within the transverse momentum range $$0\le p_{\mathrm{T}}\le 20$$ 0 ≤ p T ≤ 20 GeV/ c , depending on the particle species. The $$p_{\mathrm{T}}$$ p T spectra, integrated yields, and particle yield ratios are discussed as a function of collision energy and compared with measurements at lower $$\sqrt{s}$$ s and with results from various general-purpose QCD-inspired Monte Carlo models. A hardening of the spectra at high $$p_{\mathrm{T}}$$ p T with increasing collision energy is observed, which is similar for all particle species under study. The transverse mass and $$x_{\mathrm{T}}\equiv 2p_{\mathrm{T}}/\sqrt{s}$$ x T ≡ 2 p T / s scaling properties of hadron production are also studied. As the collision energy increases from $$\sqrt{s}$$ s = 7–13 TeV, the yields of non- and single-strange hadrons normalized to the pion yields remain approximately constant as a function of $$\sqrt{s}$$ s , while ratios for multi-strange hadrons indicate enhancements. The $$p_\mathrm{{T}}$$ p T -differential cross sections of $$\pi ^{\pm }$$ π ± , $$\mathrm {K}^{\pm }$$ K ± and $$\mathrm {p}$$ p ( $$\overline{\mathrm{p}}$$ p ¯ ) are compared with next-to-leading order perturbative QCD calculations, which are found to overestimate the cross sections for $$\pi ^{\pm }$$ π ± and $$\mathrm{p}$$ p ( $$\overline{\mathrm{p}}$$ p ¯ ) at high $$p_\mathrm{{T}}$$ p T .